- ATHE Level 6 Unit 2: Assesses the impact of leadership and management skills and behaviours : Personal Leadership and Management Development Assignment, UK
- QUALIFI Level 5 Part 02 Unit 9500: A pilot Research Project is the small scale research project that is intended to highlight the pros: Research Project, UK
- QUALIFI Level 5 Part 01 Unit 9500: Research Project, UK Professional Development Academy
- You are to prepare a discussion paper aimed at the group of middle managers in your organisation : Personal Leadership and development, Assignment, UK
- Critically analyse the environment facing YourOrg, and identify the central issues confronting YourOrg resulting : Strategic Management Assignment , CMU, UK
- Unit 15: This assignment requires you to analyse, design, develop, and evaluate an Internet of Things (IoT) application: Transport Network Design (L5), Assignment BTEC, UK
- Clearly differentiate the terms organisational mission, vision and strategy: Strategic Leadership And Management In Context, Assignment, UK
- ATHE Level 7 : Understand the importance of financial data in formulating and delivering business strategy : Finance for Strategic Managers, Assignment UK
- CMI Unit 703 : Collaboration and partnerships can turn ideas into reality, enhancing opportunities for innovation and creativity, research and development : Collaboration and Partnerships, Assignment, UK
- 7OS01- Explain how the Employment Tribunal, the County Court, The Health and Safety Executive and the Information Commissioner : Advanced employment law in practice, Assignment, UK
- ILM 308 – Describe the factors that will influence the choice of leadership styles or behaviours in workplace situations: Understanding Leadership Level 3 Assignment , UK
- Level 5 CMI Unit 526 – Mark Sheet: Principles of Leadership Practice, UK
- Level 5 CMI Unit 526 : Understanding of ethical leadership and the impact of culture and values on leadership- Principles of Leadership Practice, Assignment, UK
- CMI Unit 501: Examine the impact of legal status on the governance of an organisation- Principles Of Management And Leadership In An Organisational Context Level 5 Assignment, UK
- ILM Level 5 Effective Communication Skills, Assignment , UK
- ILM Level 3 – Describe the factors that will influence the choice of leadership styles or behaviours in workplace situations Referral : Understanding Leadership styles, Assignment, UK
- CMI Unit 502 Understand approaches to developing, managing, and leading teams: Principles of Developing, Managing and Leading Individuals and Teams to Achieve Success, Assignment, UK
- R033 Supporting individuals through life events, Set Assignment, OCR, UK
- Working in partnership in health and social care, Assignment, UK
- CMI Unit 5034 Problem solving tools and techniques for consultants, Assignment, UK
OMED0104: You have been provided with a sample that contains a counterfeit mixture of drugs: Analytical Methods and QA/QC Principles Assignment, UOG, UK
| University | University of Greenwich (UOG) |
| Subject | OMED0104: Analytical Methods and QA/QC Principles |
Question 1.
(a) Suggest a typical 2D NMR experiment that can be used for the elucidation of drug-protein interactions. Critically appraise the fundamentals of this technique and with the aid of an example, highlight how results can be monitored.
(b) You have been provided with a sample that contains a counterfeit mixture of drugs. Critically describe, with the aid of a figure, an NMR experiment that can be used to separate and identify the components in this mixture.
Question 2.
(a) Propose an experimental method, using a triple-quadrupole mass spectrometer, for the identification of an unknown drug metabolite observed during phase I clinical testing. Your answer should include:
(i) Consideration of different ionization methods, and the mass spectrometric information generated by them.
(ii) Discussion of the different mass spectrometric scanning modes available, and the information each scanning mode can provide.
(iii) Discussion of the use and limitations of gas chromatography and liquid chromatography as separation methods that supplement mass spectrometry for use with complex analyte matrices.
(b) For the low-resolution electrospray ionization of the nonsteroidal anti-inflammatory drug diclofenac, predict the pseudo-molecular parent ion mass spectrum and isotope distribution, including mass-to-charge ratios of expected peaks, and the calculated relative abundances of any isotope peaks.
Question3.
The following questions are related to chiral separations:
(a) Discuss why pharmaceutical companies care about the chiral purity of their compounds. [8 marks]
(b) Discuss how racemic mixtures are separated. [15 marks]
(c) If you must validate a specific chromatographic methodology, discuss how you evaluate the key validation parameters.
Question4.
(a) Why is the polymorphism of interest in the pharmaceutical industry? Discuss different polymorphic systems(transitions) and explain their physicochemical differences. Provide sketches of their unique DSC traces.
(b) Several experimental parameters may influence the quality of thermogravimetric analysis (TGA) data for a given pharmaceutical molecule. Critically describe the importance of heating rate, carrier gas flow, and type of carrier gas on the obtained results and their quality. Provide examples and graphical explanations to support your answer.
Question5.
(a) What are the key aspects of the analytical method selection process? Provide a detailed explanation and examples to support your answer.
(b) Explain and graphically represent a phase 1a investigation of an OOS result.
Do You Need Assignment of This Question
Homework Writing Help and Help with Assignments: UK students, specifically from the University of Greenwich (UOG), can now avail expert assistance for their coursework. If you are currently enrolled in OMED0104: Analytical Methods and QA/QC Principles, and facing challenges with the Analytical Methods and QA/QC Principles Assignment, worry no more! Our skilled professionals are here to provide you with comprehensive support. Whether it’s tackling complex problems or ensuring top-notch quality, our experts are equipped to handle it all. Don’t let academic stress hold you back; pay for our specialized help and excel in your studies at UOG, UK
Answer
