- ILM Unit-409: focused on understanding the impact of development on workplace performance: Managing Personal Development, Coursework, UOS, UK
- ILM Unit-409: focused on implementing and evaluating planned development activities and apply learning in the workplace: Managing Personal Development, Coursework, UOS, UK
- ILM Unit-409: focused on identifying and prioritising work-related development requirements: Managing Personal Development, CourseWork, UOS, UK
- 7PS032: Identify type of study design needed, including within or between groups where relevant: Research Methods Course Work, UOW, UK
- 7PS032: What do the means, range and standard deviations show?: Research Methods Course Work, UOW, UK
- 7PS032: You need to write a research proposal. It must be a quantitative research proposal: Research Methods Course Work, UOW, UK
- MN0493: Report the major points of your discussions with the client. This should include the construction of the portfolios: Investments and Risk Management Course Work, NUN, UK
- DAT7303: In portfolio 3, students must complete 4 tasks related to analysing a dataset using CRISP- DM methodology: Data Mining Course Work, UK
- BUSI 1475: Your task is to identify and select an article from the BBC News website (news.bbc.co.uk): Management in a Critical Context Course Work, UOG, UK
- COMP6029: Computer Science and Electronic Engineering related subjects generally use the IEEE referencing style: Network Systems Course Work, UOS, UK
- UMACTF-15-M: You have recently been appointed as a Financial Analyst for a leading investment bank in London: Corporate Financial Strategy Course Work, UWE, UK
- BAM5010: choose an organisation and make some recommendations for the delivery: Work Based Project Course Work, UOB, UK
- You are required to calculate ratios for Fresh Farms Ltd: financial Course Work, UK
- Understand the legal, ethical and theoretical context for health, safety and risk management: leadership and Management Course Work, UK
- P3 Describe the types of training and development used by a selected business: BTEC Business Extended Diploma Pearson Course Work, UK
- Describe how a selected business identifies training needs: BTEC Business Extended Diploma Pearson Course Work, UK
- Discuss your chosen business, background information and why you have chosen that business: BTEC Business Extended Diploma Pearson Course Work, UK
- Activity 7: Risk management in an organisation should be both sensible and proportionate to the level of risk involved: NEBOSH IDIP ID1 Research Paper Course Work, OU, UK
- Activity 6: Reviewing health and safety performance Critique your chosen organisation’s health and safety: NEBOSH IDIP ID1 Research Paper Course Work, OU, UK
- Activity 5: Management of contractors Review how your chosen organisation selects contractors and manages them while they are on site: NEBOSH IDIP ID1 Research Paper Course Work, OU, UK
CHEM1110: You are working within the pharmaceutical industry, and you have been assigned a kinase to develop an inhibitor: Computational and Medicinal Chemistry Exercise Course Work, IUB, UK
| University | Islamia University Bahawalnagar (IUB) |
| Subject | CHEM1110: Computational and Medicinal Chemistry Exercise |
You are working within the pharmaceutical industry, and you have been assigned a kinase to develop an inhibitor for. Your team has already found a compound that can moderate the activity of the kinase of interest
- Using this information, use Auto DockTools and Autodock Vina to dock your compound with the kinase of interest. Your report should include
a) A brief explanation of how you determine the search area for the docking, accompanied by a suitable picture to show where the search box is located with respect to the kinase in your docking.
b) Description of possible interactions between your compound and the kinase that you have identified after docking, accompanied by a suitable picture(s) and labeling to highlight the interactions.
c) A table to show the binding affinity of your compound and the kinase from docking
- Based on the results from the molecular docking, and also using your knowledge of medicinal chemistry, suggest FIVE changes you would make to the molecule in order to probe SAR and increase binding efficiency.To answer this question, please draw your target molecule, and highlight the proposed changes with a brief explanation as a note as to the reasons for the change with the suspected outcome(s). Your answer should be a maximum of ONE A4 page in length.
Do You Need Assignment of This Question
Explore the dynamic fields of computational and medicinal chemistry with expert guidance. Enhance your understanding of molecular modeling, drug design, and computational analysis. At Diploma Assignment Help.co.UK, access specialized assistance for your CHEM1110 exercises. Gain valuable insights into the intersection of chemistry and medicine, and develop skills to excel in computational chemistry. Unlock the potential of computational tools to revolutionize drug discovery and contribute to advancements in medicinal chemistry. You can also contacts us for the nursing assignment help in Ireland
Answer
