6PHYM003W: What is a lactate dehydrogenase (LDH) test? Briefly explain the principle of the LDH assay: Advanced Pharmacology and Toxicology Essay, UOW, UK

University University of Westminster (UOW)
Subject 6PHYM003W: Advanced

Section A: 

1. What is a lactate dehydrogenase (LDH) test? Briefly explain the principle of the LDH assay.

2. Drug development requires that a compound is tested through a series of general toxicology tests prior to entering clinical populations. Give a detailed evaluation of both in vitro and in vivo tests with appropriate details and the advantages and disadvantages of both.

3. Discuss how the metaboliser status of patients expressing CYP2D6 variants may impact prescribing decisions for treatment with codeine.

4. a) Explain what is meant by the term ‘constitutive GPCR activity’ and how
agonists and antagonists with different pharmacological properties may affect this.

b) Explain what is meant by the term ‘biased signaling’ and provide an example of where this is relevant clinically.

5. Describe microRNA (miRNA) biogenesis and mechanism of action.

Section B: 

1. Write an account detailing the clinical features of, and neurotoxicological
mechanisms thought to underlie methylmercury poisoning.

2. Describe calcium homeostasis and its role in cellular toxicity.

3. Describe what is meant by the term “rational drug design” in the context of
chemotherapy. Use ONE named example to describe how a specific chemotherapy agent was rationally designed to target a cancer-causing mutation. Discuss some advantages and disadvantages to rationally designed chemotherapies.

Buy Answer of This Assessment & Raise Your Grades

Calling all ambitious students at the University of Westminster (UOW) enrolled in 6PHYM003W: Advanced! Are you searching for reliable and professional assistance for your assignments? Your search ends here! Our platform is dedicated to providing unparalleled assignment help online to support UK students in their academic journey.

Specifically, if you require guidance with case studies, look no further. Our specialized Case Study Writing Help is designed to meet your needs and ensure your success. By paying our experts for their expertise, you gain access to invaluable knowledge and support throughout your course. Don’t let the challenges of assignments hinder your progress—seize this opportunity to excel academically. Contact us today and unlock your true potential with our trusted services!

Answer

Do You Need Assignment of This Question