- ATHE Level 6 Unit 2: Assesses the impact of leadership and management skills and behaviours : Personal Leadership and Management Development Assignment, UK
- QUALIFI Level 5 Part 02 Unit 9500: A pilot Research Project is the small scale research project that is intended to highlight the pros: Research Project, UK
- QUALIFI Level 5 Part 01 Unit 9500: Research Project, UK Professional Development Academy
- You are to prepare a discussion paper aimed at the group of middle managers in your organisation : Personal Leadership and development, Assignment, UK
- Critically analyse the environment facing YourOrg, and identify the central issues confronting YourOrg resulting : Strategic Management Assignment , CMU, UK
- Unit 15: This assignment requires you to analyse, design, develop, and evaluate an Internet of Things (IoT) application: Transport Network Design (L5), Assignment BTEC, UK
- Clearly differentiate the terms organisational mission, vision and strategy: Strategic Leadership And Management In Context, Assignment, UK
- ATHE Level 7 : Understand the importance of financial data in formulating and delivering business strategy : Finance for Strategic Managers, Assignment UK
- CMI Unit 703 : Collaboration and partnerships can turn ideas into reality, enhancing opportunities for innovation and creativity, research and development : Collaboration and Partnerships, Assignment, UK
- 7OS01- Explain how the Employment Tribunal, the County Court, The Health and Safety Executive and the Information Commissioner : Advanced employment law in practice, Assignment, UK
- ILM 308 – Describe the factors that will influence the choice of leadership styles or behaviours in workplace situations: Understanding Leadership Level 3 Assignment , UK
- Level 5 CMI Unit 526 – Mark Sheet: Principles of Leadership Practice, UK
- Level 5 CMI Unit 526 : Understanding of ethical leadership and the impact of culture and values on leadership- Principles of Leadership Practice, Assignment, UK
- CMI Unit 501: Examine the impact of legal status on the governance of an organisation- Principles Of Management And Leadership In An Organisational Context Level 5 Assignment, UK
- ILM Level 5 Effective Communication Skills, Assignment , UK
- ILM Level 3 – Describe the factors that will influence the choice of leadership styles or behaviours in workplace situations Referral : Understanding Leadership styles, Assignment, UK
- CMI Unit 502 Understand approaches to developing, managing, and leading teams: Principles of Developing, Managing and Leading Individuals and Teams to Achieve Success, Assignment, UK
- R033 Supporting individuals through life events, Set Assignment, OCR, UK
- Working in partnership in health and social care, Assignment, UK
- CMI Unit 5034 Problem solving tools and techniques for consultants, Assignment, UK
You are working within the pharmaceutical industry, and you have been assigned a kinase to develop an inhibitor for: Medicinal Chemistry Assignment, UniS, UK
| University | University Of Surrey (UniS) |
You are working within the pharmaceutical industry, and you have been assigned a kinase to develop an inhibitor for. Your team has already found a compound that can moderate the activity of the kinase of interest.
- Using this information, use AutoDockTools and Autodock Vina to dock your compound with the kinase of interest. Your report should include
- A brief explanation of how you determine the search area for the docking, accompanied by a suitable picture to show where the search box is located with respect to the kinase in your docking.
You can click “Ligand Interaction” which will bring you to a new page displaying where and how a drug molecule interacts with the kinase. You can use your mouse to rotate and zoom in/out to help you visualize the binding site.
Once you have a good understanding of where the binding site should be, you need to adjust the dimensions, scaling factor, and the center of the search box in AutoDockTools based on this information. You need to make sure you define the search box correctly in your conf.txt file. - Description of possible interactions between your compound and the kinase that you have identified after docking, accompanied by a suitable picture and labeling to highlight the interactions.
- A table to show the binding affinity of your compound and the kinase from docking.
- Based on the results from the molecular docking, and also using your knowledge of medicinal chemistry, make FIVE changes you would make to the molecule in order to probe SAR and increase binding efficiency. Your answer should be a maximum of ONE A4 page in length, should concisely describe why you are making those changes, and should include chemical drawings of your hit compound and subsequent analogs in order to visualize those changes.
Do You Need Assignment of This Question
Are you looking for report writing help in the UK? Look no further than our team of experts at Diploma Assignment Help UK. We have a team of professional assignment writers who are experienced in a wide range of report writing styles and formats, and they can help you to create a well-written report that meets all the requirements of your course. Contact us today to find out more about our academic writing services.
Answer
